Quan-Plex™ Patient-like ctDNA Panel
Description:
The Quan-Plex™ ctDNA Reference Standard is a highly-characterized, quantitative multiplex quality control that allows researchers to develop their own assays, and assess limits of detection (LODs) for eight cancer-associated solid tumor mutations. This panel can also be used to monitor the quality of their NGS or dPCR oncology-based workflow for routine quality assessment. The standards have been engineered to mimic the fragmentation profile of nucleosomal, ctDNA in patient (~166 bp) samples.
Certificate of Analysis
ARF1003CT291216 ARF1003CT291725 CTD200316Variant Information:
| Gene | Nucleotide | Amino Acid | Cosmic | Frequency |
|---|---|---|---|---|
| EGFR | 2307_2308insGCCAGCGTG | V769_D770insASV | COSM12376 | 0%, 0.1%, 1%, 5% |
| EGFR | 2573T>G | L858R | COSM6224 | 0%, 0.1%, 1%, 5% |
| EGFR | c.2369C>T | p.T790M | COSM6240 | 0%, 0.1%, 1%, 5% |
| KRAS | 35G>A | G12D | COSM521 | 0%, 0.1%, 1%, 5% |
| NRAS | c.181C>A | p.Q61K | COSM580 | 0%, 0.1%, 1%, 5% |
| PIK3CA | c.1633G>A | p.E545K | COSM763 | 0%, 0.1%, 1%, 5% |
| EGFR | 2235_2249del15 | E746_A750delELREA | COSM6223 | 0%, 0.1%, 1%, 5% |
| EGFR | 2155G>A | G719S | COSM6252 | 0%, 0.1%, 1%, 5% |
General Information:
| Catalog | ARF-1003CT | |||||||||
| Size | 1 panel | |||||||||
| Format | ctDNA | |||||||||
| Volume/Dimension | 4 vials of 7.5µl each | |||||||||
| Quantity | 300 ng/vial | |||||||||
| Concentration | 40 ng/µl | |||||||||
| Cell(s) | RKO, HCT116 | |||||||||
| Shelf Life | 24 months | |||||||||
| Buffer | Tris-EDTA (10 mM Tris-HCl, 1 mM EDTA), pH 8.0 | |||||||||
| Shipping Temperature | Gel packs | |||||||||
| Storage Temperature | -20°C (2 years Exp Date) | |||||||||
| Quality Control | Genotype: Sanger sequencing of locus-specific PCR (cell line) Quality:Bio-Analyzer™ 1000 Chip and NGS (Ion AmpliSeq Hotspot Cancer Panel V2 on Illumina) DNA Quantification: Qubit 4.0 fluorometer Mutation Allelic Frequency: Digital PCR **Quantified with NGS. Note multiple copies of the insertion may be observed with NGS. Manufacturing: ISO 9001:2015 and ISO 13485:2016 Certified |
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| Freeze/Thaw | No more than 3 cycles | |||||||||
| Regulatory | For Research Use Only. Not intended for human or animal diagnostics or therapeutics. | |||||||||
| Restrictions | This is a limited use product. This product, any material that contains this product in whole or in part, any progeny, modification or derivative of this product, any cell or animal made or modified by using this product, and any progeny, modification or derivative of such cell or animal may not be transferred by the purchaser to any other person, entity or any of the above to perform services for the benefit of any other person or entity or for commercial purpose of any kind. This product may only be used by the purchaser for its internal research for use as a research tool for research purposes. | |||||||||
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| Catalog: | ARF-1003CT |
| Price: | $450.00 |
| Availability: | Please Inquire |
